Health Awareness - Thalassemia

by Health Please

Posted on 12:03PM May 08, 2018 in General

Health Awareness - Thalassemia

What is Thalassemia?

Thalassemias are genetic blood disorders inherited from a person’s parents and are characterized by less hemoglobin and a fewer red blood cells in your body than normal. Symptoms depend on the type and can vary from none to severe.

There are two main types, alpha thalassemia and beta thalassemia. The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing.

1. Alpha Thalassemia

In alpha thalassemia, the hemoglobin does not produce enough alpha protein. To make alpha-globin protein chains we need four genes, two on each chromosome 16. We get two from each parent. If one or more of these genes is missing, alpha thalassemia will result. The severity of thalassemia depends on how many genes are faulty, or mutated.

2. Beta Thalassemia

We need two globin genes to make beta-globin chains, one from each parent. If one or both genes are faulty, beta thalassemia will occur. Severity depends on how many genes are mutated.

What is the cause of Thalassemia?

If you're missing two genes, you have alpha thalassemia trait (also called alpha thalassemia minor). You may have mild anemia. If you're missing three genes, you likely have hemoglobin H disease (which a blood test can detect). This form of thalassemia causes moderate to severe anemia.

Medical Treatment:-

  • Blood transfusions.
  • Medications.
  • Bone marrow transplant or stem cell transplant.

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