Laboratory Diagnostic Test For Dengue
by Health Please
Posted on 09:49AM Aug 21, 2018 in General
Laboratory Diagnostic Test For Dengue
It’s just another day for you at work; you handover one of the most important dossiers to your Team, signed and sealed, for execution and come back to your cabin, where a glass of cool water is kept next to one of those flamboyant paper-weights you gifted yourself recently. You sit on your comfortable high-back chair with a soft, heavily cushioned backrest, pushing it back, to relax after an eventful, busy first half. You pick up the glass of water, eyes transfixed on the gorgeous paperweight. Just as you start sipping water, you feel a light, but significant pain behind your eyes. Within moments, you also realize you have a light headache. The pain still isn’t excruciating, but it’s significant and unlike any pain you have felt so far.
By evening, the headache has gotten severe and the pain behind your eyes is a lot more pronounced. You can also sense you have high fever and the intermittent nausea you seemed to have developed doesn’t exactly let you enjoy your evening Tea. You drive back home, feeling fatigued. By late evening, your muscles and joints are already in writhing pain. Paracetamol made you feel better, but only for a couple of hours. You call up your physician. He asks you to eat an antibiotic, preferably Taxim-O, twice a day for three days and asks you to update. “If you don’t feel better, we will investigate” he assures. “Make sure you keep yourself hydrated. Drink lot of water and avoiding eating anything that’s oily and too spicy”, he reiterates. Three days later, it has only gotten worse. You have developed rashes as well, on your skin. The pain in muscles and joints has gotten worse, and the pain behind your eyes keeps visiting every couple of hours, growing in its intensity with each visit. You call up your physician. He asks you to get a few done, one of which is for . A few hours later, your physician calls you up, “You have dengue. Please get admitted”.
Dengue, pronounced as ‘DenGee’, is an enervating fever caused by the bite of mosquitoes of the Aedes type, principally A-aegypti. These mosquitoes generally occur in tropical areas, and you normally develop symptoms within two weeks after such mosquito bite. Four different viruses transfused from these mosquitoes are the basic cause for Dengue. An infected mosquito transmits the virus to humans through bite.
If the symptoms mentioned above persist in spite of medication for a period of more than three to five days, it’s recommended to get yourself tested for Dengue. There are a few
The IgM (Immunoglobulin M ELISA) and IgG (Immunoglobin G ELISA) Tests
They are basically anti-bodies Tests. Anti-bodies normally appear in the infected person’s Body four or five days after the person first showed symptoms, which is why, getting an IgM or IgG Test done right on the first day of the illness shows no results. Ideally, if you are infected and go for an IgM or IgG five days later, your blood will show anti-bodies formed to fight the virus, an obvious sign of the presence of virus in the blood stream, thus confirming Dengue. On the day five of infection, the IgM is more effective than the IgG, as it is more prominently present compared to the latter, during the initial stages of infection.
Dengue NS1 Antigen Test
Direct Virus Detection methods are generally obtained if the symptoms become more serious and troublesome even before the fifth day of infection, when the IgM or IgG cannot detect the antibodies and thus, can’t ascertain the infection. The NS1 Antigen is an initial investigation Test and it is glycoprotein synthesised by all flaviviruses and secreted from infected mammalian cells during the acute phase of infection. The method of detection is through enzyme-linked immunosorbent essay. The sensitivity of NS1 Antigen is higher in the primary infection than in secondary infection. Introduced in 2006, the NS1 Antigen Test has already been adopted by more than 40 Countries Worldwide.
The Standard Diagnostics (SD) Bioline Dengue Duo Kit
The SD Bioline Dengue Duo Kit is a rapid point-of-care test kit and is often used in the primary care setting. It is a one-step assay to detect Dengue NS1 Antigen and IgM/IgG in human serum, plasma or whole blood, and can be completed within 15-20 minutes.
MP Diagnostics Multisure Dengue Ab/Ag Test Kit
It is another Test kit used in the primary stages of the disease and can serve as an alternative option in primary care. It can accentuate dengue diagnostics in an endemic setting.
Prompt diagnosis, communication and subsequent treatment of Dengue is paramount in order to avoid any fatalities. Early management of Dengue is extremely important. Once detected early, dengue isn’t a difficult disease to treat. However, as with most of major infections, it’s dengue at an early stage and start the treatment. Definitive tests are useful and necessary for confirmation, since the symptoms Dengue shows in its primary phase are common and overlap with the symptoms of many other normal and worse conditions.
When you opt for a check-up plan, you allow your body to communicate with you in a better way. The right kind of services and treatments can give you a proper insight into your disease and make you better informed to deal with it.